Another important use of opaque functors is the following: Mac Donald (MacDonald, 1976) shows that Kan extensions of cohomological theories can be taken along rich functors; in fact, it can also be taken along opaque functors (and more in general with exact squares).
Bibliography
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MacDonald, J. L. (1976). Natural factorizations and the Kan extension of cohomology theories. Cahiers De Topologie Et Géométrie Différentielle Catégoriques, 17(1), 69–93. http://eudml.org/doc/91162Details